2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154360
    2’,3’-Di-O-acetyl-8-benzyloxy-3’-deoxy guanosine
    2’,3’-Di-O-acetyl-8-benzyloxy-3’-deoxy guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Di-O-acetyl-8-benzyloxy-3’-deoxy guanosine
  • HY-154544
    3’-O-MOE-U-2’-phosphoramidite
    3’-O-MOE-U-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-MOE-U-2’-phosphoramidite
  • HY-180664
    15H-11,12-EETA
    15H-11,12-EETA is a nucleoside metabolite.
    15H-11,12-EETA
  • HY-152332
    2’-Chloro-N6-(4-methoxy)benzyl adenosine
    2’-Chloro-N6-(4-methoxy)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Chloro-N6-(4-methoxy)benzyl adenosine
  • HY-152831
    2-Amino-8-aza-7-deaza-7-iodoguanosine
    2-Amino-8-aza-7-deaza-7-iodoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-8-aza-7-deaza-7-iodoguanosine
  • HY-180708
    3-(Methylseleninyl)-L-alanine
    3-(Methylseleninyl)-L-alanine is a nucleoside metabolite.
    3-(Methylseleninyl)-L-alanine
  • HY-154089
    3-Deoxy-1,2:5,6-bis-O-(1-methylethylidene)-α-D-ribo-hexofuranose
    3-Deoxy-1,2:5,6-bis-O-(1-methylethylidene)-α-D-ribo-hexofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3-Deoxy-1,2:5,6-bis-O-(1-methylethylidene)-α-D-ribo-hexofuranose
  • HY-154012
    2'-Deoxy-8-methylamino-adenosine
    2'-Deoxy-8-methylamino-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2'-Deoxy-8-methylamino-adenosine
  • HY-152485
    2-Amino-N6,N6-dimethyl-2’-deoxy-2’-fluoro-beta-D-arabino-adenosine
    2-Amino-N6,N6-dimethyl-2’-deoxy-2’-fluoro-beta-D-arabino-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-N6,N6-dimethyl-2’-deoxy-2’-fluoro-beta-D-arabino-adenosine
  • HY-W780282
    N6-Threonylcarbamoyladenosine-13C4,15N
    N6-Threonylcarbamoyladenosine-13C4,15N (N6-(N-Threonylcarbonyl)adenosine-13C4,15N) is the 13C- and 15N-labeled N6-Threonylcarbamoyladenosine (HY-18398). N6 - Threonylcarbamoyladenosine is a common nucleosides, which can decorate and become tRNA.
    N6-Threonylcarbamoyladenosine-<sup>13</sup>C<sub>4</sub>,<sup>15</sup>N
  • HY-152308
    3’-Deoxy-3’,5-difluorocytidine
    3’-Deoxy-3’,5-difluorocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’,5-difluorocytidine
  • HY-154121
    2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate ammonium
    2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate (ammonium) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate ammonium
  • HY-152735
    5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine
    5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine
  • HY-154248
    2’-Deoxy-3’,2-anhydrouridine
    2’-Deoxy-3’,2-anhydrouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-3’,2-anhydrouridine
  • HY-149072
    TLR7 agonist 11
    TLR7 agonist 11 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    TLR7 agonist 11
  • HY-154221
    N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine
    N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine
  • HY-W040329S3
    2'-Deoxyadenosine-15N5,d13
    2'-Deoxyadenosine-15N5,d13 is deuterium and 15N labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-<sup>15</sup>N<sub>5</sub>,d<sub>13</sub>
  • HY-154466
    5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine
    5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine
  • HY-155757
    3′-Phenylcarbamate-UTP
    3′-Phenylcarbamate-UTP is phenylcarbamate (Phenylcarbamate) modified uridine triphosphate (UTP).
    3′-Phenylcarbamate-UTP
  • HY-B1449S9
    Uridine-13C,15N2
    Uridine-13C,15N2 (β-Uridine-13C,15N2) is a 13C- and 15N-labeled Uridine (HY-B1449).
    Uridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>